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Carcinoma de Células Renais (CCR) é o cancro mais comum de rim. A taxa de novos diagnósticos CCR está a crescer 2% ao ano, um ritmo muito mais rápido do que qualquer outro cancro. Em EUA, 275.000 pacientes são diagnosticados para o cancro do rim todos os anos, e 55.000 são diagnosticados com carcinoma de células renais. A maioria dos tumores de rim são detectados como "achados incidentais" a partir de exames de imagem, como ressonância magnética ou tomografia computadorizada, realizadas por outros motivos de verificação dos rins. A maioria dos tumores (70%) são detectados em estágios iniciais, quando o tumor é pequeno. Pode ser difícil para os médicos destinguir qual dessas pequenas massas renais são malignas ou benignas. Esta incerteza resulta em cirurgias e biópsias desnecessárias, a fim de definitivamente diagnosticar a presença do cancro. Quando o CCR é diagnosticado, o tratamento resume-se à remoção cirúrgica de todo ou parte do rim afectado. Nos estágios iniciais, em que o CCR ainda não se espalhou para além do rim, a cirurgia é realizada com intenção curativa. No entanto, 20-40% dos pacientes em fase precoce que não apresentam metástase detectável no momento, acabam por mais tarde remover rim devido ao desenvolvimento de doença metastática. Não existe cura para CCR metastático, sendo que o desenvolvimento de testes para diagnosticar a presença de CCR, bem como a probabilidade de que um determinado tumor metastizar, permitirão uma melhor gestão clínica da doença.

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A Metabolon está a desenvolver um teste para detectar a presença de CCR, medindo um painel de biomarcadores de metabolitos em sangue ou urina. Este teste de diagnóstico permitirá destinguir com precisão quais as pequenas massas renais CCR e benignas. Esta informação permitirá aos médicos determinar se o paciente necessita de biópsia confirmativa ou cirurgia, ou se podem evitar estes procedimentos mantendo um programa de vigilância ativa.

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A Metabolon está a desenvolver um teste para medir metabolitos específicos extraídos a partir de uma pequena quantidade de tecido de tumor removido durante uma biópsia ou nefrectomia. Ao detectar a assinatura metabólica similar aos tumores metastáticos mais avançados (T3-T4), o teste vai identificar quais os tumores em estágio inicial (T1-T2) que são realmente mais agressivos, mas que se presumem ser de baixo/médio risco. O resultado do teste vai disponibilizar aos médicos informação adicional para além estadiamento patológico tradicional, auxiliando as suas decisões de tratamento para pacientes com carcinoma de células renais em estágio inicial.

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Após CCR ser detectado e os pacientes serem tratados por cirurgia (nefrectomia total ou parcial), os médicos fornecem cuidados de acompanhamento em intervalos regulares para verificar se existem sinais de recorrência da doença (doença metastática). Lesões metastáticas muito pequenas, conhecidas como micro-metástases, são geralmente assintomáticas e podem não ser detectáveis em exames de imagem como tomografia computadorizada ou ressonância magnética até atingirem um tamanho maior. Se estas micro-metástases forem detectados mais cedo, os médicos podem tratar o paciente mais rapidamente. A Metabolon está a desenvolver um teste de detecção da presença de metástases ocultas e assintomáticas com base num painel de metabolitos em sangue ou urina. Este teste destina-se para o tratamento de seguimento, quer juntamente com os testes de imagem padrão, ou como uma porta de entrada para os testes de imagem. Identificar a doença metastática precocemente, proporciona informações clínicas adicionais importantes na escolha da terapia mais adequada para cada paciente.

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