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Even when prostate cancer is definitively diagnosed, the clinical staging by biopsy and Gleason scoring does not necessarily correlate with pathological staging. Approximately 50% of men whose disease is thought to be localized to the prostate prior to surgery actually have tumor extension beyond the prostate1, and a significant minority has already developed metastatic disease. Determining which tumors are aggressive based on biopsy and Gleason scores is particularly challenging with intermediate Gleason scores of 6-7. Specifically, within this "gray zone" for Gleason scores, the ability to predict disease aggressiveness(such as extracapsular extension, seminal vesicle invasion, and lymph node involvement) is limited, even when prostate biopsy results are coupled with other clinical parameters such as physical exam and PSA levels.The significant unmet clinical needs in prostate cancer detection and risk assessment are the driving force behind Metabolon’s efforts to develop better diagnostics in this area.

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Metabolon’s prostate cancer detection test is based on detecting a unique metabolic signature from the pellet, which is spun down from a small urine sample taken post-DRE. This highly accurate test can be performed prior to the primary biopsy (to inform the decision to perform a biopsy), at the time of biopsy, or after a first-negative biopsy (to inform the decision to perform a second biopsy). The test can also be used during the expectant management process. Because Metabolon’s test is non-invasive, it provides additional clinical information to guide physician decision-making and improve patient management while minimizing risk to the patient and the added expense from an unnecessary biopsy.


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Biopsy is the gold standard for diagnosing prostate cancer, and the histopathology of the patient’s biopsy is one factor used to determine whether the cancer is at an early or advanced stage. Metabolon’s test measures a panel of metabolites in the prostate biopsy tissue that enables the physician to more accurately determine whether the patient’s tumor is aggressive. This test is performed on fluid in which prostate biopsy cores are soaked prior to processing by the pathologist. Metabolon’s proprietary process for metabolite extraction from biopsy cores does not compromise the biopsy tissue or alter tissue morphology. The Prostarix™ Prostate Biopsy Assessment test gives clinicians valuable information about the aggressiveness of their patient’s prostate cancer, enabling improved decision-making in the clinical management of the patient’s disease.

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